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Re: toxic crap » morgan miller

Posted by linkadge on July 24, 2010, at 21:53:53

In reply to Re: toxic crap, posted by morgan miller on July 24, 2010, at 19:54:07

>This complicates the interpretation of the >results of the study. It is possible that >nortriptyline has no BBB effects in the absence >of barbiturate.

No, because in a separate reference to this study, they compared nortriptyline and cloropromazine with the barbituate to various doses of diphenhyramine with barbituate. The diphenhydramine (a bicyclic) had no effect at any dose tested, with the barbituate.

See p 33

http://books.google.ca/books?id=9ykQOkpFFuEC&pg=PA33&lpg=PA33&dq=micellar+drugs+%2B+chlorpromazine+%2B+nortriptyline&source=bl&ots=53da_ifB39&sig=sU02PQmATTVB5BOohvSXgnwf60o&hl=en&ei=_qZLTMeJGoL_8Ab1tYk1&sa=X&oi=book_result&ct=result&resnum=1&ved=0CBQQ6AEwAA#v=onepage&q=micellar%20drugs%20%2B%20chlorpromazine%20%2B%20nortriptyline&f=false

Linkadge

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URL: http://www.dr-bob.org/babble/20100720/msgs/955784.html