Posted by Christ_empowered on June 15, 2010, at 23:49:48
In reply to can you take Parnate with Amitriptyline?, posted by sophia04 on June 15, 2010, at 1:31:11
Hey. I googled that combo and tca+maois. It looks like tca+maois were used together in patients a good bit in the 60s, I guess before they realized a) maois can be dangerous and b) adding a reuptake inhibitor to the mix can make things tricky. I also found some studies from the 80s suggesting improved response to the combo (as opposed to either alone) in a treatment-resistant subset of patients. The only TCA I saw that was absolutely *not* to be mixed with an MAOI was clomimpramine. On the other hand, I also saw an article reporting that, based on a limited sample of patients, TCA+MAOI combos really weren't that great and the potential benefits were far outweighed by the very real health concerns.
It seems to me that a MAOI+stimulant combo would be more likely to work and the results would probably be more predictable (they were still using stimulants pretty often for depression well into the 70s, so I imagine there's a good bit of data and experience on amphetamines+MAOIs).
Whatever combo you end up on, I just hope you take into consideration the limited benefits available from drug treatment and the very serious risks you may be taking, especially over the long haul. That said: I wish you well.
poster:Christ_empowered
thread:951089
URL: http://www.dr-bob.org/babble/20100615/msgs/951205.html