Posted by em_kath on June 13, 2010, at 12:35:07
In reply to Re: Emsam: Did everyone give up on it?, posted by former poster on June 13, 2010, at 12:15:42
> In my experiences, taking a long time to kick in could be an indicator that it is very effective. I am having a hard time finding general information on Emsam. I thought that since in its originally a parkinsons drug it worked primarily on dopamine. This stuff makes me feel like I drank a whole pot of coffee.
My understanding is that at the 6 mg dose Emsam is selective for MAO-B, so it works mainly on dopamine, and once you go past 9 mg it loses its selectivity for MAO-B and reduces the breakdown of MAO-A, at which point it also works on serotonin and norepinephrine. If you feel agitated on a lower dose maybe a higher dose would have a calming effect once you have the benefit of serotonin, although I suppose the norepinephrine could contribute to agitation as well.
poster:em_kath
thread:950865
URL: http://www.dr-bob.org/babble/20100604/msgs/950900.html