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Re: Valproic Acid Linked To Congenital Malformations » linkadge

Posted by SLS on June 12, 2010, at 6:46:28

In reply to Re: Valproic Acid Linked To Congenital Malformations, posted by linkadge on June 11, 2010, at 18:20:31

Hi Linkadge.

Thanks for taking the time to respond. I wish I had your memory. Maybe one day...


- Scott


> I know that gsk-3b inhibitors have mood stabilizing effects. Gsk-3b is increased by stress and attenuated by mood stabilizers (and some antidepressants like fluoxetine). It has some effect on circadian rhythms, neuronal inflammation as well as blood glucose regulation. GSK-3b inhibiton also affects the sensitivity of 5-ht1b receptors as well, GSK-3b inhibiton also reduces the developement of beta amyloid.
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> In terms of development of the fetus, not exactly sure. It has some effect on the outgrowth of nerve cells. Mild GSK-3b inhibition in humans appears to have neurotrophic effecs, while as higher doses are neurotoxic. It is linked somehow with beta catenin and bcl-2, which regulate cell survival, nerve growth etc. I'm not a molecular biologist though.
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> There is some info here (page 5) with regards to the effects of teratogenic effects of valproate. In this case it is in reference to its HDAC inhibiting effects.
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> http://www.biochemsoctrans.org/bst/037/1126/0371126.pdf
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> Linkadge
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