Posted by linkadge on May 9, 2010, at 14:10:34
In reply to Re: Question for Linkadge (anyone can comment though) » SLS, posted by ed_uk2010 on May 9, 2010, at 12:59:05
To play the devils advocate, some would say that surmontil is not an effective antidepressant. Although comparitively, doxapin does not have the same affinity for monoamine uptake (compared with antihistamine action), it still has affinity for 5-ht2m muscarinic receptors as well as opiate receptor interaction.
Although highly sedating, in clinical doses of 75mg (if you can tollerate it) doxapin is (IMO) an effective antidepressant. It has marked HPA normalizing and sleep improving effects. This alone, would be expected to produce intrinsic AD effect (at least with certain depressions).
Linkadge
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