Posted by SLS on April 27, 2010, at 12:52:18
In reply to Re: Prednisone and Immediate AD Response, posted by bulldog2 on April 27, 2010, at 10:51:27
How do you think this figures in?
I'm having a hard time understanding this stuff.
Is your baseline cortisol level high or low?
My baseline salivary cortisol is high and I am a dexamethasone non-suppressor.
I tried a one-week treatment using mifepristone. It didn't help. However, I felt sort of washed-out afterwards. Do you think this was from adrenal exhaustion? I don't know.
- Scott
--------------------------------------------------
Antidepressant treatment with mirtazapine, but not venlafaxine, lowers cortisol concentrations in saliva: A randomised open trialBarbara ScharnholzaCorresponding Author Informationemail address, Bettina Weber-Hamannb, Florian Lederbogena, Claudia Schillinga, Maria Gillesa, Vera Onkena, Pascal Frankhauserc, Daniel Kopfd, Michael Deuschlea
Received 4 January 2009; received in revised form 17 August 2009; accepted 26 August 2009.
AbstractLowering the concentrations of free cortisol in depressed patients may be an important prerequisite to prevent glucocorticoid-related sequelae of depression. We tested the hypothesis that the hypothalamuspituitaryadrenal (HPA) system-dampening effects of venlafaxine and mirtazapine differ. We compared the course of morning (08.00h) and afternoon saliva cortisol (16.00h) in 42 mirtazapine- and 45 venlafaxine-treated depressed patients during a 1-week wash-out and a 4-week treatment period in a randomised open trial. Mirtazapine lowered afternoon cortisol from week 1 to 4. In contrast, during the course of the entire treatment period, venlafaxine did not attenuate saliva cortisol concentrations. Treatment effects of mirtazapine on cortisol concentrations did not differ in remitters and non-remitters to treatment. High baseline cortisol concentrations, on the other hand, were related to an unfavourable course during venlafaxine treatment and patients remitting during venlafaxine treatment had significantly lower afternoon cortisol concentrations in saliva, when compared to non-remitting patients. Thus, mirtazapine and venlafaxine show different effects on HPA system activity as measured by saliva cortisol. This may be of relevance with regard to physical sequelae of depression
--------------------------------------------------
The measure of achievement lies not in how high the mountain,
but in how hard the climb.The measure of success lies only in how high one feels he must
climb to get there.
poster:SLS
thread:945160
URL: http://www.dr-bob.org/babble/20100425/msgs/945277.html