Posted by ed_uk2010 on April 18, 2010, at 8:19:53
In reply to Re: ultram, really..., posted by bulldog2 on April 17, 2010, at 17:59:57
>Acetaminophen is starting to get another look for side effects. The milligrams have been downed in the states to 2000 for safety. Apparently a lot of people were ending up with liver failure.
Minor elevation of liver enzymes (notably alanine aminotransferase) seem to be quite common in patients on long term acetaminophen but this does not represent liver damage. Many drugs cause minor elevations.
http://www.ncbi.nlm.nih.gov/pubmed/17076974
Acetaminophen causes far fewer adverse effects at recommended doses than any other oral analgesic. The recommended dose in the UK for chronic pain is 1000mg four times a day. Thousands of people take it on a daily basis. It can take the edge off the pain, even if it is not strong enough on its own. Tolerance does not develop, which is a major bonus. For severe pain, it is usually combined with other pain relievers for enhanced efficacy.
Problems with acetaminophen are normally related to:
A. Deliberate overdose
B. Taking several acetaminophen products together without realising that they all contain the same drug. This is most common with opioid combination medicines.
poster:ed_uk2010
thread:943398
URL: http://www.dr-bob.org/babble/20100416/msgs/943805.html