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Cymbalta- dose related fatigue? or adjunct meds? » Lou Pilder

Posted by SLS on April 13, 2010, at 7:31:06

In reply to Lou's request » gman22, posted by Lou Pilder on April 12, 2010, at 21:15:12

> > ask the doctor if you can take amitriptyline or nortriptyline in the mean time. they usually help right away with most symptoms (especially anxiety) and both of these are proven safe to take with Maoi's. They actually reduce the chances of hypertensive reaction.

> gman22,
You wrote,[...proven safe to take with Maoi's...]
Couuld you post here a link to an article that substantiates that? If you could, then I could have the opportunity to respond accordingly.
Lou


Ok.


- Scott


----------------------------------------------


http://www.ncbi.nlm.nih.gov/pubmed/727903

Arch Gen Psychiatry. 1978 May;35(5):639-42.
A comparison of electroconvulsive therapy and combined phenelzine-amitriptyline in refractory depression.

Davidson J, McLeod M, Law-Yone B, Linnoila M.
Abstract

Combined monoamine oxidase (MAO) inhibitor-tricyclic antidepressant therapy and electroconvulsive therapy (ECT) were compared in a population of refractory depressive patients. Seventeen patients were randomly assigned to either of the treatment groups, and an independent observer was used to rate overall progress. Between four and ten ECTs or a combination of phenelzine and amitriptyline were administered. Assays for MAO activity and plasma levels of amitriptyline and nortriptyline were performed. In both psychotic and neurotic depression, ECT was superior. When depression was accompanied by character disorder, the response was generally poor. Adequate levels of MAO inhibition were obtained, but tricyclic antidepressant levels were low. Electroconvulsive therapy is still considered to be the treatment of choice for severe depression, whereas the combination of low doses of phenelzine and amitriptyline are ineffective. This treatment modality needs further investigation.


---------------------------------------


http://www.ncbi.nlm.nih.gov/pubmed/7484185


"Acta Psiquiatr Psicol Am Lat. 1994 Dec;40(4):314-20.
[Combined therapy with tricyclic and MAOI antidepressants in the treatment of resistant major depression]

[Article in Spanish]

Rosan TA, Mesones HL, Brengio F.
Abstract

This paper shows the results of associating tricyclic and MAOI antidepressants in the treatment of resistant major depression. Forty five patients from private practice with diagnosis of major depression according to DSM III R criteria, with negative response to separate tricyclic or MAOI treatment, were given both types associated. They improved without dangerous side effects."


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