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Re: Generic Fluoxetine Vs. Prozac

Posted by bleauberry on March 9, 2010, at 16:49:27

In reply to Generic Fluoxetine Vs. Prozac, posted by morganator on March 8, 2010, at 20:23:39

If I got a dollar for every report I've heard about a problem with a generic I would have a pretty darn good savings account. Fluoxetine happens to be one of the more commonly mentioned ones.

I've read some rather intricate reports explaining why generics can be sub-therapeutic compared to brand, despite that they are supposedly the same active ingredient. Pretty fascinating stuff most of us don't think about and are not aware of.

One of my doctors had so many patients relapse on generics and then bounce back on brand that he won't even prescribe generics.

To be fair, some people do fine on generic. Some people do better on generic than brand. It happens. Not as much, but it happens. Generics themselves can vary a lot from one manufacturer to another.

Is your dose the same as it was on Symbyax? If I recall correctly, the prozac dose in symbyax is 25mg? To get that extra odd 5mg you would have to do the orange juice trick. Or maybe your dose is different? Not sure. Just a thought.

There is one way to challenge it and see for sure. Call your doctor and ask him to call in a prescription for brand prozac.

Naysayers will claim it is your imagination or placebo effect. I would guess maybe in a very small percentage of people that is true, but in the majority it is false. There is more to this issue than we know.

When I was switched from brand prozac to generic fluoxetine, I was stable. I did not know I had been switched. I thought the capsules looked a little different, but didn't give it any thought. Immediately I noticed that the "buzz" I got from prozac in the 6 hour period following a dose was gone. And while brand prozac gave me some sleep problems, I no longer had those problems on generic. So something was different. At my next appointment I talked about my deterioration with my doctor. He said maybe it was because of the switch to generic. I said, "huh?" I didn't even know I had been switched. An increase in dose of the generic only brought on agitation and feeling worse. A return to brand prozac pretty much fixed the whole issue back to normal within a couple days. I knew it was the real stuff because I had that 6 hour warm buzz again.

I estimate it will be another 5 tyo 10 years before this topic gets the attention it deserves. Just know, you aren't alone in your experience.

Bioequivalence does not equal therapeutic equivalence. Simple as that. Brands had to go through lengthy trials. Generics did not. You and me are the realworld live guinea pigs.


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poster:bleauberry thread:938946
URL: http://www.dr-bob.org/babble/20100305/msgs/939014.html