Posted by SLS on January 17, 2010, at 12:32:33
In reply to Re: Scott, posted by bleauberry on January 17, 2010, at 12:06:28
Hi Bleauberry.
I am grateful that you took the time to post this. It is going to take me a while to read it all. I have thought about naltrexone, but never looked into it enough to learn how to go about using it. I would have to sell my doctor on the idea, though.
Thanks.
- Scott
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> Hi Scott. Was thinking about you this morning.
>
> Did you discontinue Parnate already? I thought maybe you were in the process of weaning off it?
> What else are you taking?
>
> Hey, I know this is going to sound crazy because it doesn't fit the scientific clinical proof point of view that you are accustomed to. But seriously, I mean real serious, please consider LDN along with whatever you do.
>
> I look back on your history and I see every possible tweaking of serotonin, NE, DA, sodium/calcium channels, on and on.
>
> Endorphins.
>
> I don't think anyone knows the extent to which our natural endorphins play in health and disease, except that in LDN communities they are proving to be profounding involved in psychiatric mood disorders, immune system regulation, thyroid and adrenal regulation. I mean, we're talking everything from Crohn's disease to Lyme to Hashimotos to gluten intolerance to depression and everything inbetween.
>
> One single 50mg pill equals 50 doses. What harm is there in trying such a small amount? None. What potential benefits are there? Tons.
>
> I can only say from my own viewpoint, LDN is good for rapid mood improvement (in combination with something else, not that strong by itself), energy restoration, brain-fog elimination, renewed interest in life, anti-anxiety without sedation, very smooth mood stabilization, and geez, how can such a tiny amount do all that?
>
> The theory is that blocking the opioid receptors for a short time with a small dose interrupts the feedback loop and causes the creation of more endorphins, up to 300% more the following day. And we both know that blocking a receptor will eventually cause them to become more sensitive and responsive when they are opened up, in addition to increasing the numbers of them. So, a lot more endorphins, receptors that can enjoy them, and well, it makes sense for improving mood.
>
> Nortriptyline + Zoloft + LDN. You might feel like your old self before all this crap began, in a matter of 3 days.
>
> I would have to put together several dozens, maybe a hundred, of comments from LDN users, as well as the small pilot studies and open studies done, to back up my hunch this could well be that missing link in your life, but I don't want to do that. Trust me. LDN is for real.
>
> I remember a long time ago, 12 years maybe, in Dr Bobs Psychopharmacology tips there was a doctor who discovered that Naltrexone reversed Prozac poopout, and created remission in partial responders. There was a group of us here that tried it, and it was a fad for a while, but no one could duplicate that doctor's results.
>
> Today we know why. The 25mg and 50mg he was using were far too high, blocking the opioid receptors strongly 24/7. That's the wrong approach. We only want to block them weakly for a few hours.
>
> Even at my dose of 25mg though I could tell there was a lot of something else going on besides merely blocking opioid receptors. I am totally convinced those receptors are intricately communicative with serotonin and dopamine. Again, I could go into a long story of my own experiences and literature explaining that, but just trust me. Too much stuff.
>
> LDN. No matter what it is you do going forward, whether it is a SSRI + TCA, SNRI + TCA...make sure 1mg Naltrexone goes along with it. A 50mg pill can be crushed and then 1/50th crumbs estimated, or get your doctor to call in a prescription to a compounding pharmacy. If you do a google search on LDN you'll find a home page that has the most experienced LDN compounding pharmacies listed.
>
> This is kind of awkward because I feel like the student making suggestions to the expert teacher that you are, but I would also strongly suggest a protocol of Diflucan 100mg twice a week for 4 or 5 months. I know you eat yogurt everyday and that's a good thing. I feel that by itself is not enough to ward off the opportunistic environment created by longstanding stress on the body due to feeling bad for so long, and the unavoidable chronic ingestion of pharmaceuticals. Excess yeast/fungi in the gut and body feels every bit as bad and the same as the DSM depression. Being a fast metabolizer, Diflucan will also slow things down a little bit. There is liver risk with daily usage, but it is nontoxic and safe for long periods of time when taken weekly.
>
> I have no doubt you are making plans for your next ADs. I wholeheartedly desperately want to see things work. To increase the odds of that happening, I am totally absolutely 100% convinced LDN and Diflucan will make the game-winning touchdown. Not by themselves however. They need to go with SSRI/TCA, SNRI/TCA.
>
> Unlike the myriad of choices we have in the pharmaceutical world, these two meds offer a distinctly unique profile...very high potential, near zero risk, zero side effects. As I see it, there is no argument anyone could make to not try them.
>
> I hate it when people say, "Have a good day." They have no idea. But I will wish for you my favorite line, "Have a smooth day." Better days are ahead for you, I can see it.
>
> Fondly and respectfully.
> Bleauberry
poster:SLS
thread:933932
URL: http://www.dr-bob.org/babble/20100113/msgs/934042.html