Posted by Brainbeard on December 25, 2009, at 9:20:14
In reply to Re: sertraline and nort.-bleauberry, posted by linkadge on December 24, 2009, at 20:38:53
> Nortriptyline helped me sleep. According to its clinical profile it shouldn't, but it did. I would certainly take it at night.
>
> LinkadgeThere are several reasons why nortriptyline would help people sleep:
* It's an NRI. Noradrenergic reuptake inhibition can have the paradoxical side-effect of making people sleepy. Atomoxetine (Strattera) is infamous for it. Geodon's (ziprasidone's) sedation is probably also noradrenergic for the bigger part.
* It has antihistaminergic i.e. sedating properties.
* It does some 5HT2A-antagonism, which promotes deep sleep.
See http://www3.interscience.wiley.com/cgi-bin/fulltext/121665024/main.html,ftx_abs#t3 for receptor affinities.
poster:Brainbeard
thread:930705
URL: http://www.dr-bob.org/babble/20091217/msgs/930814.html