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Re: sertraline and nort.-bleauberry

Posted by Brainbeard on December 25, 2009, at 9:20:14

In reply to Re: sertraline and nort.-bleauberry, posted by linkadge on December 24, 2009, at 20:38:53

> Nortriptyline helped me sleep. According to its clinical profile it shouldn't, but it did. I would certainly take it at night.
>
> Linkadge

There are several reasons why nortriptyline would help people sleep:

* It's an NRI. Noradrenergic reuptake inhibition can have the paradoxical side-effect of making people sleepy. Atomoxetine (Strattera) is infamous for it. Geodon's (ziprasidone's) sedation is probably also noradrenergic for the bigger part.

* It has antihistaminergic i.e. sedating properties.

* It does some 5HT2A-antagonism, which promotes deep sleep.

See http://www3.interscience.wiley.com/cgi-bin/fulltext/121665024/main.html,ftx_abs#t3 for receptor affinities.


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poster:Brainbeard thread:930705
URL: http://www.dr-bob.org/babble/20091217/msgs/930814.html