Posted by bulldog2 on December 12, 2009, at 13:21:19
In reply to Re: Swapping Parnate for Effexor. » bulldog2, posted by SLS on December 12, 2009, at 11:48:07
> > I've read of pdocs who combine nardil with parnate. Obviously lower doses of both would be required. Each drug has its own neurotransmitters ratios and maybe when combined you have the potential to hit that elusive sweet spot called remission.
> There was one person on PB that I remember trying it, but he never followed up to tell us what happened. Although the thought of combining the two MAOIs has occurred to me, a doctor at NYU pretty much scared me out of giving it further consideration. He said that his staff had seen strokes result from an inadequate washout period when switching from one drug to the other. I know that my current doctor would not entertain the idea.
> - Scott
Let's examine the idea. There are four irreversible maois currently on the market(nardil,marplan,parnate,emsam). Each one has cases where one has worked where the others have not. So each maoi while in theory boosts neurotransmitters also has something unique. Now there are supposed to be cases where nardil and parnate have been blended to yield a new blend that has worked.
I would search for these cases or studies and see wether this has actually occurred. What doses were used and were there specific ratios that were used such as 50 to 50 . Were there any cases of serotonin syndrome? How safe is this method when certain controls are in place.
The following has always baffled me. Nardil appears to hit serotonin more strongly than parnate. Does one get serotonin syndrome when the dose of nardil goes to high? So why does parnate which seems more norepinephrine oriented precipitate serotonin crisis if used in low doses with nardil?