Posted by bulldog2 on November 30, 2009, at 13:50:34
In reply to Re: Is ritalin a dopamine releaser? » conundrum, posted by Phidippus on November 29, 2009, at 21:08:38
> Methylphenidate exerts its therapeutic effects via blocking the reuptake of dopamine into nerve terminals (as well as stimulating the release of dopamine from dopamine nerve terminals) resulting in increased dopamine levels in the synapse. Methylphenidate is a norepinephrine and dopamine reuptake inhibitor, which means that it increases the level of the dopamine neurotransmitter in the brain by partially blocking the dopamine transporter (DAT) that removes dopamine from the synapses. This inhibition of DAT blocks the reuptake of dopamine and norepinephrine into the presynaptic neuron, increasing the amount of dopamine in the synapse. It also stimulates the release of dopamine and norepinephrine into the synapse. Finally, it increases the magnitude of dopamine release after a stimulus, increasing the salience of stimulus.
I saw where tramadol supposedly antagonizes nmda receptors. Would this prevent stimulant tolerance. Some seem to believe that nmda antagonists prevent stim tolerance.