Posted by SLS on November 26, 2009, at 6:42:42
In reply to Re: klonopin success and then the other way! » mogger, posted by SLS on November 25, 2009, at 23:10:24
Now that I think about it, I recall one study of clonazepam that reported a reduced turnnover of serotonin due to a reduction in its release from nerve terminals. This might explain the 5-HT1 receptor upregulation. It might also explain why some people get depressed while taking clonazepam.
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> Clonazepam-induced up-regulation of serotonin1 binding sites in frontal cortex of rat
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> H. R. Wagner2, 1, A. Reches2 and S. Fahn2
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> 1 Departments of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, U.S.A
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> 2 Departments of Neurology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, U.S.A
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> Accepted 18 February 1985.
> Available online 6 November 2002.
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> Abstract
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> Chronic administration of the benzodiazepine, clonazepam, increased the number of [3H]-hydroxytryptamine (5-HT1) binding sites in the frontal cortex of the rat. The increase reflected a change in the maximum density of binding sites (Bmax) with no change in ligand affinity (Kd). Increased binding occurred after continued exposure (10 days) to large (5.0 mg/kg) doses of clonazepam. The changes in [3H]5-HT binding were regional in that they occurred in membranes from the frontal cortex but not the brainstem. The effects were also at least partially selective for 5-HT receptors since the binding of the β-adrenergic radioligand, [3H]dihydroalprenolol, was not affected by clonazepam. A second benzodiazepine, diazepam, did not affect the binding of [3H]5-HT at doses of 30 mg/kg per day. The latter data suggest that the effects of benzodiazepines on serotonin 5-HT1 receptors are unique to clonazepam.
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poster:SLS
thread:926987
URL: http://www.dr-bob.org/babble/20091117/msgs/927023.html