Posted by bleauberry on November 24, 2009, at 17:55:16
In reply to what med has the least emotional flattening?, posted by snubbel on November 24, 2009, at 7:10:33
Moclobemide has a pretty poor track record. Most doctors gave up on it years ago.
You touched on the serotonin thing and I agree with you. While serotonin probably plays a part, it needs to be kept as a minor player, not a major player.
Best ideas I can think of. You mentioned Effexor...not. Too much serotonin. Wellbutrin...maybe. This med doesn't work that great very often, but when it does it works really good.
Best bet as I see it...low dose SSRI with a TCA such as Nortriptyline first, Desipramine second. The TCA+SSRI combo is hard to beat.
If you are into mailorder meds, I have never known a better med for your cluster of symptoms than Amisulpride 25mg.
Adrafinil first, or Provigil second, added to a low doses SSRI is also promising. Sometimes Provigil all by itself.
Some ideas for you. I agree with your hunch that too much serotonin is worsening things for you. If depression truly is a chemical imbalance as they theorize, well, then it has to be balanced out with norepinephrine and/or dopamine as well, not just serotonin.
poster:bleauberry
thread:926792
URL: http://www.dr-bob.org/babble/20091117/msgs/926867.html