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Re: Do DA agonist and APs increase cognition?

Posted by metafunj on October 27, 2009, at 20:09:07

In reply to Re: Do DA agonist and APs increase cognition?, posted by g_g_g_unit on October 27, 2009, at 19:49:17

I appreciate the posts. It seems like any drug that can increase DA transmission may be able to improve at least concentration and maybe even memory.

Regarding Atypical APs. At a low dose they antagonize the D2 autoreceptor. This is the receptor that when activate inhibits the release of dopamine. So when its activated by DA it acts as a DA brake. When you antagonize it you disinhibit the release of DA. This is what low dose APs do. When you take an atypical at a higher dose it starts to block the post synaptic receptor which decreases dopamine transmission. This is presumabley when the antipsychotic part of the medication takes a effect.

Also atypical APs also antagonize certain serotonin receptors that cause the release of more dopamine.

Has Zyprexa or any one else noticed weight gain at these lower doses of APs?

 

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poster:metafunj thread:922915
URL: http://www.dr-bob.org/babble/20091021/msgs/922987.html