Posted by bulldog2 on October 25, 2009, at 13:25:03
In reply to Why antidepressants don't work for so many, posted by jrbecker76 on October 25, 2009, at 9:44:54
I have no idea how her study was done and it has to be go through a trial of review to see if her results are truely valid. My thoughts:
1. First she used gene analogy and I don't even understand that concept.
2. Yes rats have similar brains but the differences can be huge in the final result.Most drugs that have passed the rat testing phase do not make it through human testing and that number is well of 90%. Until this testing goes though dogs, champanzees and finally people you can't assume her results have any validity.
3. Peta wants to stop aninal testing based on their investigations that show a low correlation between rats and even higher animals to humans.
4. I believe there are tests that do correlate stress with depression! Autopsies on depressed people have shown enlarged andrenals which seem to indicate chronic stress.
5. In my situation chronic stress seems to almost always lead to depression. I know others who say that is true for them also and others like one of the posters above who don't have that correlation.
6. I still believe that depression is not a disease but a symptom of possibly many diseases. The flaw in the research that looks for drugs for this disease is that rearch in reality is looking for a drug that will control this symptom so you end up with drugs that help about somewhat over 60% of people.
7. Actually I believe maois in some studies (one on parmate) helped over 90% of people who remained. High dropout rate due to sides.
8. Rat studies at best are an indication to further study the new concept.
9. I noticed some in this thread have already excepted her concept as a proven truth. At this point it is a hypothesis.10. But I feel one point is important. Science needs to find the cause or causes of depression. Than pharm companies can find truley effective drugs. She's right about since ssris and snris we really haven't put anything novel out there
11. What is sad is that the most effective drugs (maois) for those that can endure the sides and restrictions and they are over 50 years old are the best drugs out there.
12. While these rat studies are interesting and may need further research please don't assume that that is now a proven true. IT'S A HYPOTHESIS FOR NOW.
poster:bulldog2
thread:922361
URL: http://www.dr-bob.org/babble/20091021/msgs/922387.html