Posted by doxogenic boy on September 22, 2009, at 12:17:08
In reply to Buprenorphine for depression, posted by Jimmyboy on September 21, 2009, at 15:34:52
> Is anyone out there that looks at this board still taking buprnorphine successfully to treat their depression?
---I have tried it three times, the first time it worked best (about 4-5 months). But I felt terrible when I woke up. At that time it wasn't a big problem, because I knew that I would feel wonderful in about two hours after the morning dose. But when buprenorphine stopped working I had developed cross-tolerance; a very short period on morphine, had only a modest effect.
And then came the withdrawal - this was really the worst time of my whole life. The anxiety was extreme all the time for 2-3 months and I become hospitalized. And that is only half the story.
> I know over the last few yrs there have been a few people on here who took it and had succes but have not seen them post in awhile. This is a good sign as most people would not continue to come to this site if they were in "remission"
----I think the opposite way: they probably are embarrassed because the buprenorphine stopped working; I haven't heard of any lasting antidepressant effect from continuous use of opioids for years.
If the opposite was true, then the opioids would be the best antidepressants for ever. I think it would have been more research into it if they were the ideal antidepressants.
The cases reported about buprenorphine and other opioids - why don't we hear more from those patients? I think it is a publication bias - the psychiatrists are not likely to report something is bad later when they first reported dramatic antidepressant effects. Or maybe they just lose contact with the patients.
For short time use, opioids may work, but I don't know how fast the tolerance buildup comes.
> Any additional info of using bupe for depression and/or anxiety would be appreciated.Here are some links about buprenorphine and some about other opioids.
http://www.thieme-connect.com/ejournals/abstract/pharmaco/doi/10.1055/s-2005-918797
http://balder.prohosting.com/~adhpage/bupe.html
http://www.opioids.com/refs/index.html
http://www.ncbi.nlm.nih.gov/pubmed/19442177
http://www.opioids.com/tolerance/paincontrol.html
Excerpt from article:
Jhamandas and colleagues have found that in vanishingly small doses, opioid antagonists - normally used to block the toxic effects of opioids - instead enhance pain-killing action in experimental models. As well, they discovered that the development of tolerance to morphine was inhibited, and in cases where tolerance had already developed, it was actually reversed.
[...]
Combining an opiate "agonist" like morphine with its "antagonist" - in this case, the drug naltrexone - is a radical approach that was inspired by suggestions in the scientific literature that opiates have both stimulatory and depressant effects, says Jhamandas. Both types of drug act on opiate receptors which are located on nerve cells that transmit pain signals. When activated by morphine, these receptors will powerfully suppress pain.
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http://www.ncbi.nlm.nih.gov/pubmed/12007745http://www.ncbi.nlm.nih.gov/pubmed/16364263
http://www.ncbi.nlm.nih.gov/pubmed/18354712
http://www.ncbi.nlm.nih.gov/pubmed/8901000
http://www.ncbi.nlm.nih.gov/pubmed/9352573
doxogenic
poster:doxogenic boy
thread:917958
URL: http://www.dr-bob.org/babble/20090921/msgs/918035.html