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Re: Sleep drug - Ciltyri (Eplivanserin) delayed » yxibow

Posted by SLS on September 22, 2009, at 5:12:14

In reply to Re: Sleep drug - Ciltyri (Eplivanserin) delayed » SLS, posted by yxibow on September 22, 2009, at 0:35:15

> > > FDA cite's problem with the drug's "benefit-risk" profile....
> > >
> > > http://www.fool.com/investing/general/2009/09/17/sleepless-in-sanofi.aspx
> >
> >
> > Is this drug a true hypnotic or does it improve the neurobiology of the underlying disorder by blocking 5-HT2a receptors? If it is not sedating, it might make an interesting augmenter of antidepressants.
>
> Possibly.... but if a drug meant for sleep has no sedating qualities, is it really good for people who have bad insomnia (like myself) ?


Just guesswork:

Two things come to mind. First, is the example of using an antidepressant devoid of direct sedative or anxiolytic properties to treat anxiety disorders. Second, is the circadian rhythm phase advance that agomelatine produces, something that is known to reduce depression.

I am not sure that melatonin has direct hypnotic properties per se as we would assign a benzodiazepine, even though it can help initiate and maintain sleep. I am playing with semantics a bit by using the word "direct". The example here is the person whose ideal time for taking melatonin is in the afternoon. Again, it is a matter of manipulating the circadian rhythms that produces the desired effect.

How would you describe the current popularity of Rozerem (ramelteon), the melatonin receptor agonist? I don't see that it is used very often at all. Perhaps it is being used improperly. With melatonin, timing is everything.


- Scott

 

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