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Re: seratonin receptors and libido - help plz.

Posted by linkadge on September 13, 2009, at 11:00:47

In reply to seratonin receptors and libido - help plz., posted by Jimmyboy on September 13, 2009, at 8:46:11

I'm not exactly sure. I know that 5-ht1a agonists have a facilitatory effect on certain aspects of sexual function.

5-ht2c antagonism supposedly reverses the negative effects of serotonin reuptake inhibition on sexual function. On the other hand, I think acute 5-ht2c agonism can facilitate certain aspects of sexual function (erection etc.)

Not sure about 5-ht2a. I know 5-ht2a agonism release oxytocin, so this might facilitate certain aspects of sexual function.

I think I remember reading that 5-ht2c antagonism and 5-ht2a agonism had synergistic effects on sexual function in some rodent model of sexual dysfunction.

OTOH, I think 5-ht2c agonism is what is responsible for the anti-premature ejaculation effects of SSRI's.

So, perhaps if ejaculation is premature, 5-ht2c agonism is beneficial, but if it is latent (or impossible) some degree of 5-ht2c antagonism is beneficial.

Linkadge



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URL: http://www.dr-bob.org/babble/20090912/msgs/916866.html