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Re: Parnate technical

Posted by SLS on August 31, 2009, at 15:53:28

In reply to Re: Parnate technical, posted by SLS on August 31, 2009, at 15:49:33

The Parnate (tranylcypromine) molecule itself acts like amphetamine in that it produces an increased release of norepinephrine and possibly an inhibition of reuptake:


Am J Psychiatry 126:925-931, January 1970
doi: 10.1176/appi.ajp.126.7.925
1970 American Psychiatric Association

Tranylcypromine: Effects on Norepinephrine Metabolism in Rat Brain
JOSEPH J. SCHILDKRAUT M.D.1

1 Neuropsychopharmacology laboratory, Massachusetts Mental Health Center, 74 Fenwood Rd., Boston, Mass. 02115, assistant professor of psychiatry, Harvard Medical School

This investigation examines the effects of tranylcypromine on the uptake, release, and metabolism of intracisternally administered tritiated norepinephrine (norepinephrine-H3) in rat brain. The findings suggest that, in addition to being a potent inhibitor of the enzyme monoamine oxidase, tranylcypromine discharges norepinephrine extraneuronally onto receptors and possibly also inhibits the neuronal reuptake of this amine. These neuropharmacological effects of tranylcypromine may possibly account for the greater clinical efficacy of tranylcypromine in the treatment of some depressed patients and the higher incidence of hypertensive cerebrovascular reactions when this drug is compared with other monoamine oxidase inhibitors.

 

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