Posted by SLS on August 24, 2009, at 4:53:57
In reply to Re: Nardil withdrawal » SLS, posted by FredPotter on August 23, 2009, at 20:51:35
I tend to be cautious about switching between Parnate and Nardil. Several CVAs (stokes) have been reported when people have waited less than two weeks between them. One of my doctors told me that his department actually had an incident of CVA when a patient waited for only 10 days. Yet, Jay Amsterdam, MD has switched people more rapidly.
> Someone told me that at 63 I probably have a lot of MAO in my brain stem. This person also said MAOIs prevent Alzheimer's and Parkinson's Disease.
I have seen the same thing written. I believe the authors have referred to selegiline and rasagiline. Both of these drugs have propargylamine moities (a molecular subunit), which might be key to their neuroprotective effects. Parnate and Nardil are not propargyl derivatives, and do not offer as much protection from free radicals or amyloid formation, although they do offer some through the inhibition of MAO-B. Neuroprotection might not depend upon MAO inhibition, though. Rasagiline is probably going show itself to be more potent than selegiline as a neuroprotective. I am curious to know if clorgyline, an irreversible inhibitor of MAO-A would also demonstrate neuroprotection since it, too, is a propargyl derivatave. I haven't found anything on that.