Posted by SLS on August 19, 2009, at 18:32:43
In reply to Will I damage my brain if I go cold turkey?, posted by Maxime on August 19, 2009, at 17:54:00
> Hi
>
> I see my pdoc on Monday (can't wait!) and will be asking for Parnate. I am 99.9 percent certain that he will give it to me. If I go cold turkey off of 60mg of Cymbalta and 300 mg of Wellbutrin XL, is it possible to cause brain damage? I'm sorry for such a silly question, but I am just concerned.That's a great question. I guess the answer will depend on who you talk to. I always prefer using some sort of taper in order to prevent a withdrawal syndrome from occurring.
It is my personal belief that the abrupt discontinuation of SSRI/SNRI drugs can cause a process known as kindling. Kindling causes someone to become more and more sensitive to future discontinuations and increases their severities. It might even cause future "sensitivities" to these drugs. Again, these ideas are mine. They are far from being fact. However, the resulting inference is that one might be able to minimize withdrawal by using anticonvulsants or benzodiazepines. Trileptal and Topamax might be particularly effective. I am not so sure about Depakote.
I don't think the abrupt discontinuation of Wellbutrin will produce any untoward events.
- Scott
poster:SLS
thread:913023
URL: http://www.dr-bob.org/babble/20090818/msgs/913033.html