Posted by SLS on August 16, 2009, at 6:19:22
In reply to Re: Going back to old-school - lithium. » hyperfocus, posted by SLS on August 14, 2009, at 6:08:54
Since 600mg of lithium has not produced a sustained improvement, I have decided to reduce my dosage down to 300mg and perhaps remain there for the long-term. I find that the higher dosages of lithium blunt my affect and rob me of my personality. I feel worse. These things were starting to appear at the 600mg. I should probably get a lithium blood level after I have been at 300mg for a week or two. I would hope that it be close to 0.3 mmol/L. This is the minimum level that some researchers feel that neuroprotection (bcl-2;BDNF) and neurogenesis (CREB) take place. In the long-term, I don't see how reversing the loss of brain tissue seen in mood disorders could hurt - except, perhaps, if it were to occur in Brodmann area 25 (ventral anterior cingulate cortex). Here, neurons are over-active in depression. Deep brain stimulation (DBS) serves to short-circuit this area, leading to reduced neurotransmission.