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Re: Has Anyone Taken Tramadol (Ultram) With An SSRI?

Posted by Brainbeard on July 25, 2009, at 11:50:02

In reply to Re: Has Anyone Taken Tramadol (Ultram) With An SSRI? » Brainbeard, posted by SLS on July 25, 2009, at 6:16:54

> Anyway, back to tramadol.
>
>
> - Scott

Two things, before we get back to tramadol:

a) That link doesn't work. You're probably referring to the page I tried to indirectly link to elsewhere: (Quoting myself) 'There is a nice presentation by Stahl on the web where he explains how 5HT2A and -C-antagonism result in increased dopamine release. I can't give a direct link because it seems to be a subscription page; nevertheless, when you follow the following link and click on the first search result, you do end up in the presentation: http://www.google.nl/search?hl=nl&safe=active&rlz=1B3GGGL_nlNL255NL258&q=Schizophrenia%3A+From+Circuits+to+Symptoms+Presented+by+Stephen+M.+Stahl&btnG=Zoeken&meta='

b) Stahl is confused about the type of 5HT2 antagonism. Since Geodon has much more affinity for the 5HT2A than the 5HT2C-receptor, he must have meant 5HT2*A* rather than -C antagonism.

5HT2A-antagonism is indeed all I'm looking for - but the bargain comes with several other mechanisms at least, it seems. I tried low dose Prozac as a 5HT2C-antagonist (see Stahl also, same link), but it gave me rapid weight gain.

Ceteram censeo tramadol scribendam esse.

(If that was a grammatically and syntaxically correct Latin phrase, someone buy me a beer.)


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URL: http://www.dr-bob.org/babble/20090721/msgs/908493.html