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Re: Nortriptyline Generic or Brand Favorites?

Posted by linkadge on July 15, 2009, at 15:26:14

In reply to Re: Nortriptyline Generic or Brand Favorites?, posted by SLS on July 15, 2009, at 7:31:56

>Well. actually, neither do I. But you and I do >not have 25 years worth of patient experience >either. I guarantee you my doctor would not be >doing this just for grins. And being generics, >there certainly isn't any under-the-table motive >involved. He has seen what he has seen. >Different is different.


Not necessarily. Patients are unreliable. There are so many other factors that can be responsible for a patient relapsing. Patients want, however, to believe that their recovery is the result of just one factor (for example an antidepressant).

Antidepressant trials too are not reliable. In one study, drug A will beat drug B and in another study drug B will beat A. That one generic does better than another in some study doesn't mean anything.

People relapse all the time but people want *something* to blame their relapse on. I have never seen a *blinded* A-B-A traial design which proves that a patient relapses when switching to generic and then gets better when returning to the original drug. All of the studies showing patients relapsing on generic drugs are unblinded.

I believe that aside from bioequivilancy, there is no difference between one generic to another. So long as the company knows how to synthesize the drug properly.

I mean take SLS. Ok so he relapsed when he switched to generic lamotrigine. No offense SLS, but you are relapsing all the time, drug change or no drug change.

Linkadge


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URL: http://www.dr-bob.org/babble/20090709/msgs/906906.html