Posted by bleauberry on June 19, 2009, at 18:43:42
In reply to Re: Question about med combinations, posted by tonyz on June 18, 2009, at 21:57:54
When I said in my earlier response to try to get some serotonin enhancement into the mix, what I meant specifically was adding an SSRI such as Zoloft of Prozac. Nortriptyline goes well with either.
Nortriptyline is thought of as an SNRI, with its strongest action on norepinephrine. But, one has to conclude that its effects on serotonin are minimal if any, evidenced by the fact that people take Nortriptyline with MAOIs and do not get serotonin toxicity syndrome. If its reuptake of serotonin was at all meaningful, it would be a deadly combination with MAOIs.
That's why I think serotonin is the missing link in the cocktail.
Seroquel and Valium need to be replaced. Zypexa alone would be a ton better. If not quite enough, Xanax instead of Valium.
Nortriptyline+Zoloft(or Prozac)+Zyprexa+optional Xanax. Brand not generic on the Zoloft, Prozac, Zyprexa, and Xanax (Greenstone generic is good).
poster:bleauberry
thread:901793
URL: http://www.dr-bob.org/babble/20090611/msgs/902116.html