Posted by garnet71 on May 25, 2009, at 20:04:08
In reply to Re: Prolactin - Meds - Dopamine » Phillipa, posted by garnet71 on May 25, 2009, at 19:54:19
I made a mistake--it was pergolide that was deemed unsafe; i think it was just taken off the market.
From Wiki:
The drug is in decreasing use, as it was reported in 2003 to be associated with a form of heart disease called cardiac fibrosis.[2] This problem is thought to be due to pergolide's action at the 5-HT2B serotonin receptors of cardiac myocytes, causing proliferative valve disease by the same mechanism as ergotamine, methysergide, fenfluramine, and other serotonin 5-HT2B agonists, including serotonin itself when elevated in the blood in carcinoid syndrome. Pergolide can rarely cause Raynaud's phenomenon. Among similar antiparkinsonian drugs, cabergoline but not lisuride exhibit this same type of serotonin receptor binding.[3] In January, 2007, cabergoline (Dostinex) was reported also to be associated with valvular proliferation heart damage.[4] In March 2007, pergolide was withdrawn from the U.S. market due to serious valvular damage that was shown in two independent studies.[5]
poster:garnet71
thread:897596
URL: http://www.dr-bob.org/babble/20090524/msgs/897652.html