Posted by sowhysosad on May 21, 2009, at 5:33:40
In reply to Re: Avoid serotonergics after bad SRI reaction? » sowhysosad, posted by SLS on May 20, 2009, at 22:11:33
Hmmm. At the moment I'm tolerating small quantities of caffeine OK, although there have been occasions over the last few weeks where it's made me a little agitated and down.
Not to the same extent as nicotine though - until earlier this week cigarettes were causing pretty bad anxiety and dysphoria.
> Glutamate does not normally cross the blood-brain barrier in humans. However, MSG has been shown to destroy nerve cells when fed to young animals.
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> How does coffee (caffeine) affect you? If you had overactive glutamatergic activity, I imagine you would feel very uncomfortable taking caffeine - dysphoria and anxiety. Caffeine is an adenosine receptor blocker. Normally, the stimulation of these receptors helps put the brakes on glutamatergic activity as it is an inhibitory modulator. With these receptors being blocked, glutamate activity might run amok in certain individuals. This is all guesswork on my part. I have yet to form a hypothesis of what one's reaction to caffeine would be if they were chronically hypoactive as you believe you might be. There is just too much about glutamate dynamics that I don't understand. I am looking forward to hearing how caffeine affects you.
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> - Scott
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poster:sowhysosad
thread:896671
URL: http://www.dr-bob.org/babble/20090515/msgs/896937.html