Posted by desolationrower on April 6, 2009, at 8:55:41
In reply to Re: How are reuptake ratios expressed? » sowhysosad, posted by Larry Hoover on April 6, 2009, at 8:29:39
larry explained that well, the only thing i'd add is that the binding is http://en.wikipedia.org/wiki/Sigmoid_function sigmoidal. this is relevant when the drug binds to two different receptors, like velafaxine. that rapid increase in the middle of the curve means that the first receptor gets almost full before the other one really gets going, which is why you only start to get a little bit of NA effect at a high dose of venlafaxine, especially since the binding is quite different. i think there is a article on this on preskorn's site, if you search there.
-d/r
poster:desolationrower
thread:888069
URL: http://www.dr-bob.org/babble/20090330/msgs/888950.html