Posted by desolationrower on March 28, 2009, at 23:52:48
In reply to I want to switch from nortriptyline to desipramine, posted by SLS on January 3, 2009, at 16:30:10
also, i think its good you are concerned for your health. i wonder if a fibrate might be better (if you take it, i think green tea would be good supplement). might want to look into the PPAR system, like everything else it probably has psychiatric effects. while i started reading, caome across this, which is interesting since nadil reduces gluconeogenesis i think:
Mice lacking PPAR{alpha} have elevated free fatty acid levels and fatty livers, consequences of their inability to combust fatty acids. Not surprisingly, these mice are hypoglycemic as a result of their reliance on glucose as an energy resource and the lack of fatty acidderived carbon chains for gluconeogenesis.46 PPAR{alpha} agonists fail to induce peroxisomal proliferation in PPAR{alpha}-deficient mice, a genetic proof of principle, although not specifically relevant to human biology. This is one of several examples of biological divergence in PPAR biology between mice and humans. Species-specific differences are clinically relevant, given some of the animal toxicity observed with PPAR agonists and how such data can influence drug development.47 PPAR{alpha} effects also may vary, depending on different tissue locations. Although PPAR{alpha} agonists have been suggested to decrease weight,4850 recent data with PPAR{alpha} overexpression in mouse muscle suggest that PPAR{alpha} may promote obesity-related diabetes.51 The relationship of these findings to PPAR{alpha} in humans is not clear. Although much remains to be understood, PPAR{alpha} clearly is a molecular sensor of the metabolic milieu and a functional nodal point coordinating the transcriptional regulation of energy balance and lipid metabolism. The role of metabolism and energy balance in determining vascular responses makes the potential importance of PPAR{alpha} in the vasculature clear.
poster:desolationrower
thread:872122
URL: http://www.dr-bob.org/babble/20090322/msgs/887520.html