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Re: are there any pure dopamine reuptake inhibitors?

Posted by desolationrower on March 28, 2009, at 20:13:22

In reply to Re: are there any pure dopamine reuptake inhibitors? desolationrower, posted by myco on March 27, 2009, at 11:32:33

> Are these available in natural forms? I know nothing of these...time to look at pubmed.
>
> In the end doesn't an agonist produce the same results as an inhibitor for a step in the pathway?...or do you get a "serge" after the inhibitor wears off?
>
> myco
>
> -----------------
>
>
> > dopamine beta-hydroxylase
> >
> > but dopamine agonists aren't the same as substances which block teh DAT.
> >
> > -d/r
>
>

agonist will have some distribution in the brain. an inhibitor will have a different one. and the inhibitors effects will be much stronger where the enzyme is more prevalent. mao and comt don't have the same distribution, either in brain structures, or extra/intra cellularly, neuronal/glial, etc.

mentioned enzyme is the one that takes DA->NA. i i think disulfiram is an inhibitor.

-d/r

 

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URL: http://www.dr-bob.org/babble/20090322/msgs/887462.html