Posted by Larry Hoover on March 24, 2009, at 7:20:42
In reply to 25(OH)D insufficiency 1,25(OH)2D above upper limit, posted by iforgotmypassword on March 23, 2009, at 19:58:59
> Other than possible added fatigue, i personally have never noted any effect from vitamin d supplementation, even though my latest results are quite wierd.
5000 IU for maybe a week or two may not produce effects which enter into consciousness, but I can assure you that your body is "conscious" of the difference.
> My latest levels were a bit of a paradox:
>
> 25-hydroxy vitamin D was 50 something.
> 1,25-dihydroxy vitamin D was 280 something.
>
> My psychiatrist gave the results to me over the phone, so I don't have a copy of my own yet, but he said the first one was listed as insufficiency, and the second as well above the upper limit. I was supplementing 5000 IU every day when I remembered for about a week or two, continuing from what I had been rx'd the last time I took vitamin d but was too lazy too refill and forgot about it. (Initially, I had no detectable levels of 25(OH)D.)
>
> He doesn't know what to suggest from observing the results, but I guess I should go see my GP or naturopath? I have discontinued the vitamin d supplementation now. It still seems wierd since 5000 IU isn't necessarily that high a dose and seems quite common, and especially since I am still "insufficient" in 25(OH)D stores. Could there be something else causing this I should be worried about?Probably not. Once I looked, the answer really wasn't hard to find at all.
Low vitamin D status leads to high levels of white blood cells. One type of those cells, the macrophage, has the capacity to convert 25-(OH)D to 1,25-(OH)2D. The simplest explanation is almost always correct.....this is a temporary situation arising because your vitamin D levels were so low before treatment. In effect, your body is so ramped up seeking any scrap of vitamin D that it is briefly going to over-react, until it can settle down into a new stable state.
Just to be thorough, there may be a possibility that you have an underlying granulomatous disorder. Again, this is mediated by macrophages.
I strongly recommend that you resume vitamin D supplementation. Your 25-(OH)D is still way low. The other will normalize soon. If, after three months of steady supplementation, your 1,25-(OH)2D levels are still elevated, then it may be time to investigate further.
> When the numbers are all perfectly normal, can I expect some benefit in terms of physical and mental energy and cognitive clarity?Those would be reasonable expectations....depending on general improvement in diet. I don't suspect that vitamin D deficiency has occurred in a vacuum. And getting your vitamin D levels stabilized should be accompanied with enhanced calcium and magnesium intakes, at the very least. Vitamin D isn't going to fix everything.
Lar
poster:Larry Hoover
thread:886672
URL: http://www.dr-bob.org/babble/20090322/msgs/886778.html