Posted by SLS on March 21, 2009, at 16:49:22
In reply to Re: Nuvigil (armodafinil) » SLS, posted by dcruik518 on March 21, 2009, at 15:12:17
> Do you know what the difference is from Provigil and if it makes any difference in it's effectiveness for Bipolar? Maybe they've just tweaked the molecule a bit to ensure they can keep getting profits when provigil goes generic.
I am sure that making money is a prime motivating factor for developing the R- enantiomer of modafinil. I would guess that its longer half-life would require less frequent dosing, an extended drug effect, and a smoother let-down. If I had my choice regardless of price, I would choose the Nuvigil over the Provigil. Provigil is a weak inhibitor of dopamine reuptake. It has yet to be seen whether or not Nuvigil is more potent in this regard.
I always wondered if adding Provigil to a Parnate would be effective for bipolar depression. It might at least help prevent the daytime sleepiness that Parnate produces for some people.
- Scott
poster:SLS
thread:885897
URL: http://www.dr-bob.org/babble/20090313/msgs/886438.html