Posted by myco on March 17, 2009, at 18:43:39
In reply to Re: What medication should I try after all has fai, posted by desolationrower on March 17, 2009, at 2:57:15
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I think your theory is truth actually d/r...there seems to be support in the literature for it. One example I just came across is a study (have yet to go to the Univ to copy it) that indicates people who have high levels of cortisol in them prior to phenylzine treatment demonstrate a higher failure rate.
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J Clin Psychiatry. 1987 Dec;48(12):480-2.Pretreatment dexamethasone suppression test as a predictor of response to phenelzine.
Janicak PG, Pandey GN, Sharma R, Boshes R, Bresnahan D, Davis JM.
Illinois State Psychiatric Institute, Chicago.
Twenty inpatients who met Research Diagnostic Criteria and DSM-III criteria for depression underwent a 2-week washout period before the administration of a pretreatment dexamethasone suppression test (DST); the patients then received the monoamine oxidase inhibitor (MAOI) phenelzine. The mean MAO inhibition level achieved during treatment was greater than 80%. On the basis of clinical global evaluation and changes in Hamilton Rating Scale for Depression scores, 7 of the 9 baseline DST suppressors were classified as responders, 1 as a partial responder, and 1 as a nonresponder; of the 11 baseline DST nonsuppressors, 3 were responders, 1 a partial responder, and 7 nonresponders. The Mann-Whitney U test yielded p less than .02, indicating that an abnormally high pretreatment level of cortisol in response to the DST appeared to be predictive of nonresponse to phenelzine.
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>One of my theories is that underlying poor health makes it less likely ADs will work; vitamin d3 and magnesium/zinc come to mind b/c of their interaction with the dopaminergic and nmda systems, respectively. it could be i focus on my health because its easier than fixing my head.
poster:myco
thread:884934
URL: http://www.dr-bob.org/babble/20090313/msgs/885801.html