Posted by myco on March 16, 2009, at 13:18:13
In reply to Re: Tell me about PARNATE's BP issues please., posted by Phillipa on March 16, 2009, at 12:51:33
oooo thanks hun, you rock :o)
good study pick-------------
> Well here's something. Phillipa
>
> Efficacy and tolerability of tranylcypromine versus phenelzine:
> a double-blind study in antidepressant-refractory depressed inpatients
> by
> Birkenhager TK, van den Broek WW,
> Mulder PG, Bruijn JA, Moleman P.
> Departments of Psychiatry,
> Erasmus Medical Centre, Rotterdam,
> The Netherlands.
> t.birkenhager@erasmusmc.nl
> J Clin Psychiatry. 2004 Nov;65(11):1505-10
>
> ABSTRACT
> BACKGROUND: The aim of this study was to examine whether phenelzine is a suitable alternative to tranylcypromine in antidepressant-resistant depression. METHOD: A total of 77 severely depressed in-patients, meeting the DSM-IV criteria for major depressive disorder, who failed to respond to fixed plasma level treatment with either tricyclic antidepressants or fluvoxamine were withdrawn from psychotropic medication and included in a double-blind flexible-dose 5-week comparison of tranylcypromine and phenelzine. RESULTS: Of the 77 patients, 67 (87%) completed the trial, of whom 35 (52%) responded. No significant differences in response between both drugs were observed. Seventeen (44%) of 39 patients responded to tranylcypromine and 18 (47%) of 38 to phenelzine (> or = 50% reduction in Hamilton Rating Scale for Depression [HAM-D] score). The mean reduction in HAM-D score was 10.4 8.3 for the tranylcypromine sample versus 8.3 8.4 for the phenelzine-treated patients. Only a few patients (10%) used concomitant psychotropic medication. A substantial number of patients experienced severe side effects, mainly dizziness, agitation, and insomnia; the incidence was the same in both samples (21%). CONCLUSION: No difference in efficacy was observed between both monoamine oxidase inhibitors in a sample of patients with severe antidepressant-refractory depression. Phenelzine appears to be a suitable alternative to tranylcypromine
poster:myco
thread:885622
URL: http://www.dr-bob.org/babble/20090313/msgs/885633.html