Posted by bleauberry on February 27, 2009, at 17:17:59
In reply to Re: Being Med-Sensitive. » bleauberry, posted by SLS on February 27, 2009, at 9:44:54
> Hi Bleauberry.
> When you first departed on your odyssey of treatment with antidepressants, were you med-sensitive?
> Do you have an example of a drug that you were once able to take in large amounts for which you cannot take now?
> - Scott
Well, let's see, the first ever was Paxil at 10mg for a week and then 20mg after that and then 30mg. Except for the obvious sexual problems, piece of cake.
Prozac 10mg for 4 days then 20mg. A slight bit of the prozac jitters for a couple weeks and the sleep problems, but basically a pretty mild introduction to a new med.
In my early psych journey, normal doses of just about anything felt rather benign overall.
Zyprexa 5mg smooth as could be.
3 or 4 large coffees a day no prob.
But after about 8 years, all that changed fairly rapidly within a timeframe of perhaps 6 months. The first I noticed was a progressing intolerability of my usual coffee. After that it just all progressed downhill fast.
What am I NOT sensitive to? Hmmm. That's a tough one. Well, Ibuprofen is fine. Olive Leaf Extract is fine (a potent herbal antimicrobial/anti-inflammatory). I seem ok with modest doses of vitamin D or vitamin E, a modest dose of selenium or zinc, but not at all tolerable of any of the other minerals, and especially not tolerable at all in any way to B vitamin supplementation at any dose. The absolute worst are Bs, magnesium, and lithium. I recently tried SAMe for 2 days at 200mg and it was tolerable just fine other than the headache, and its rapid acute antidepressant and antipain effect was a surprise.
I have no idea if this is more anecdotal suggestive evidence of a longterm ssri syndrome, or perhaps a pathology of Lyme or Lyme-like (my LLMD sees this with nearly all his patients), a pathology of exposure to unusually large amalgams (not that many at chelation forums seem sensitive like me), or a combination of all the above.
It is a very frustrating situation because it seriously limits the ability to try things, regardless if they are vitamins, herbs, or medicines. The only good side is that if there is to be any benefit from a supplement, it is noticed quickly and at a tiny dose. Example, milnacipran at a mere 6mg bid deserved a standing ovation in producing perhaps a 30% improvement from baseline in under 2 weeks. Heck, that is half the starting dose.