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Re: Washout period from Nardil to Parnate?

Posted by Ron Hill on February 24, 2009, at 3:27:33

In reply to Washout period from Nardil to Parnate?, posted by mickapoo on February 22, 2009, at 15:19:02

> He did not mention if I should stop cold turkey and immediately start Parnate the next day?

Mick,

The Parnate Prescribing Information document specifies a washout period of at least a week with a low dosage start-up of Parnate. See the last paragraph on page two:

http://us.gsk.com/products/assets/us_parnate.pdf

On the other hand, the Nardil Prescribing Information document specifies a washout of 14 days between the discontinuation of Nardil and the start-up of another antidepressant. The document is not clear whether or not MAOIs are to be included under the category of antidepressants. See the paragraph starting about 16 lines down from the top of page 3:

http://www.pfizer.com/files/products/uspi_nardil.pdf

If it were me, Id rather be safe than sorry. Id go with the 14 days that Scott and others have mentioned above.

Also, since your p-doc did not provide you with adequate information, you might find it beneficial to read the entire Parnate Prescribing Information document.


-- Ron

dx: Bipolar II, with ultra rapid cycling (15 days for one complete cycle), and mild OCPD
300 mg/day Trileptal
200 mg/day Lamictal
250 mg/day Keppra
60 mg/day Nardil

P.S. I plan to switch from Nardil to Parnate in the very near future due to a 50 pound Nardil-induced weight gain.


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