Posted by shasling on February 5, 2009, at 14:20:52
In reply to Re: ADVANCED WAYS TO FIGHT / REDUCE MAOI POOP OUT!!!!!, posted by shasling on February 5, 2009, at 7:26:55
Here is just a snip of a case where Parnate and other stimulating maois were used as Pre treatment to the gaba effect of Nardil.
"The antidepressant/antipanic drug phenelzine (PLZ) is both an inhibitor of, and a substrate for, monoamine oxidase (MAO). PLZ also causes an elevation of brain levels of the amino acid neurotransmitter gamma-aminobutyric acid (GABA); this action can be reversed by ~pretreatment with the MAO inhibitor tranylcypromine (TCP)~, suggesting that the GABA-elevating effect is largely the result of a metabolite of PLZ formed by MAO. In the present report, rats were pretreated with the nonselective MAO inhibitor TCP, the MAO-A inhibitor clorgyline and the MAO-B inhibitor (-)-deprenyl: at the doses used, clorgyline and (-)-deprenyl caused selective inhibition of MAO-A and MAO-B, respectively. Both TCP and (-)-deprenyl caused a greater reduction in the GABA-elevating action of PLZ than did clorgyline, suggesting that MAO-B is more important than MAO-A in the formation of the active metabolite of PLZ. The results also suggest that an effect other than, or in addition to, inhibition of GABA transaminase by the metabolite may be important in the GABA-elevating action."
I find this odd since i recently read that parnate affects gaba b .Man making sense of any of it we need a chemisct here.
Here is the direct link,which again also includes other interesting links.
poster:shasling
thread:877945
URL: http://www.dr-bob.org/babble/20090203/msgs/878250.html