Posted by CaptainAmerica1967 on January 17, 2009, at 1:50:28
In reply to Re: GHB, Oxytocin, D-Cycloserine, others off-label, posted by Cseagraves on January 16, 2009, at 12:24:49
I took GHB, Xyrem, regulary while on Nardil when I went out to socialize (helped)at a very very low dose and prior to bed at a higher dose to enhance growth hormone release from the pituitary as well as the sleep enhancing effects. You may need less sleep on Xyrem as the half life is short and when the dopamine rebound occurs, you might wake up and it can cause anxiety then so if you do you it, you should use it at very very low doses for disinhibition to overcome the agoraphobia and not for sleep. I liked the fact (I get the same effect from MAOIS anyways) that I would only have to sleep 4 hours and feel like I've sleep 8hrs with Xyrem.
I've never experienced fatigue on MAOIs and in fact just the opposite where as SSRI, SNRI, TCAs all gave me fatigue. Xyrem will help with fatigue if you have it, but like I mentioned it does have a rebound effect of dopamine (GHB increases serotonin for antidepressant and antianxiety effects, binds to GABA-b receptor for the antianxiety antifear disinhibition, and slightly increases dopamine in one part of the brain giving a heightened libido and growth hormone releasing effect while suppressing dopamine in another part of the brain that when it wears off produces alertness and wakefulnes (sometimes anxiety) which is why it's indicated for narcolepsy and excessive daytime sleepiness.
Hope this helps.
poster:CaptainAmerica1967
thread:873284
URL: http://www.dr-bob.org/babble/20090104/msgs/874475.html