Posted by CaptainAmerica1967 on January 12, 2009, at 14:44:22
In reply to Re: MAOI TX in Severe+Resistant Depression » CaptainAmerica1967, posted by Phillipa on January 12, 2009, at 0:23:48
Unfortunately, I don't think selegiline in pill form (I had tried it at a dosage of 40-60mgs when it first came out) or patch will ever be effective in treating severe depression as it's primarily an MAOI type B inhibitor and type B mainly works on dopamine and phenylethylamine (the bodies natural aphrodisiac). It did boost my sex drive.
The other reversible MAOI's like moclobemide isn't very effective in my opinion either even though it's a type A, it is very weak, and is a short-acting. It did nothing for me.
Unfortunately, the drug companies cannot get past the fact that they should be working on making better MAOIs like Parnate, Nardil and Marplan, but they continue to focus on the reversible ones that they think the physicians will feel more comfortable in prescribing having less potential for a hypertensive crisis or serotonin syndrome. There's a new reversible MAOI going through clinical trials called Tyrima, but will probably be as only as effective as moclobmide.
(http://www.neurotransmitter.net/newdrugs.html)However, were the drug companies to develop medications like Parnate and Nardil in the patch form, they most likely would sell very well.
poster:CaptainAmerica1967
thread:873284
URL: http://www.dr-bob.org/babble/20090104/msgs/873557.html