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could nefazodone get any more peculiar?

Posted by iforgotmypassword on December 28, 2008, at 17:39:22

http://www.journals.elsevierhealth.com/periodicals/bps/article/PII000632239390310A/abstract

"Nefazodone significantly increased plasma levels of prolactin (PRL) and raised oral temperature. There was also a trend towards an increase in plasma cortisol. These results are consistent with an acute facilitatory effect of some aspects of 5-HT neurotransmission, perhaps mediated through nefazodone's metabolism to its major metabolite, m-chlorophenylpiperazine (mCPP)."

this may be wrong, i was under the impression that a 5-HT2a antagonistic mechanism would lower cortisol, so i am thinking either the mCPP metabolite much more significant than imagined, or the drug is much messier than it already looks. and prolactin...?


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URL: http://www.dr-bob.org/babble/20081223/msgs/871201.html