Posted by Larry Hoover on December 20, 2008, at 21:38:28
In reply to Luvox(fluvoxamine) and grapefruit?, posted by crittercuddler on December 18, 2008, at 2:06:14
Fluvoxamine (Luvox) is a primary substrate of enzyme 1A2, with lesser dependency on 2C9, and 2C19. Even lower still are its dependencies upon 2D6 and finally 3A4, the latter being the enzyme on this list which is inhibited by grapefruit. In the end, I can only conclude that the warning with respect to grapefruit and Luvox is based on an abundance of caution, rather than a truly important interaction.
An interaction that might concern you, however, is Luvox with caffeine. Metabolism of caffeine is severely inhibited by Luvox, with a half-life about five times what would normally occur.
Regards,
Lar
poster:Larry Hoover
thread:869370
URL: http://www.dr-bob.org/babble/20081214/msgs/869949.html