Posted by crittercuddler on December 16, 2008, at 3:14:02
In reply to Re: Long-Term Users of SSRI's--Need Your Help, posted by crittercuddler on December 16, 2008, at 3:12:52
I found this too...
Here are some tidbits I have found while researching. Perhaps they can be helpful.
1.Inositol may reverse desensitization in serotonin receptors. If I understand correctly that is the mechanism behind poop out, right?
Fux M, Levine J, Aviv A, Belmaker RH: Inositol treatment of obsessive
compulsive disorder. Am J Psychiatry 153:1219-1221, 1996.
As noted above, there is now considerable evidence that
pharmacologic manipulation of the serotonergic system may help with OCD
symptoms. Myo-inositol is a ubiquitous carbohydrate that is present in large
amounts in brain tissue and is involved in neuronal signaling and
osmoregulation (Vadnal et al, 1997) and, the phosphatidylinositol cycle is
the second messenger system for several neurotransmitters, including several
subtypes of serotonin receptors (Hoyter et al, 1994). In addition,
desensitization of serotonin receptors is reversed by the addition of
exogenous inositol (Rahman & Neuman, 1993). There are reports that exogenous
inositol was effective in controlled trials for patients with depression and
panic, and recently a research group performed a double-blind, controlled
crossover trial of 18 grams/day of inositol versus placebo for 6 weeks each
(Fux et al, 1996). The subjects had significantly lower scores on the YBOCS
when taking inositol than when taking placebo."