Posted by SLS on December 4, 2008, at 17:40:20
In reply to Re: To Scott - Why TCAS Are More Effective Than SSRIs?, posted by desolationrower on December 4, 2008, at 14:25:49
I am in agreement with the both of you. I do think that the 5-HT2 blockade is important when assessing the efficacy of the TCAs. However, the anticholinergic properties of these drugs might also contribute to their therapeutic effect. ACh and DA systems need to be in balance.
To paraphrase Desolationrower: location, location, location. I can hardly believe how most psychopharmacologists fail to take into consideration the loci of accumulation of various drugs and the circuits they affect when developing theories as to how antidepressants and other psychotropics work.
- Scott
poster:SLS
thread:866651
URL: http://www.dr-bob.org/babble/20081204/msgs/866715.html