Posted by jrbecker76 on November 30, 2008, at 1:01:51
In reply to Re: Agomelatine/Valdoxan/Melitor, posted by dapper on November 29, 2008, at 0:57:19
I noticed that the sleep disruption subsided after a week or so, and then finally started to actually have some sleep-maintenance effects at that point. The only real side effects I had were some mild headache and tiredness... which both faded after the first couple of days. Antidepressant effects subtly built over the first 2-3 weeks. I ended up going up to 50 mg, and had better efficacy with no real trade-off of side effects.
Agomelatine is not a robust antidepressant in itself (at least for those of us with more entrenched forms of depression), but I do see it as a good first-line therapy for those with mild-to-moderate depression. Equally, it has the potential to be a good augmenter.
I have actually used Rozerem (ramelteon) with somewhat similar success after my trial of agomelatine ended. Consequently, I am now quite certain that the melatonergic action of agomelatine is responsible for at least part of its antidepressant/anxiolytic efficacy.