Posted by Medline on November 25, 2008, at 13:43:38
I decided to try out the quite risky treatment of Moclobemide + Escitalopram. I know all risks and if it does not work the way I hope I will go for the "real" MAOI route via Parnate (of course without any other serotonergic agent!).
There have been some older studies that show Moclobemide + SSRI might be effective in treatment resistant mood disorders. However these studies are small and direct or indirect conflict of interest is a real possibility.
AFAIK combining SSRIs with RIMAs is definitively less dangerous than combining MAOIs with serotonergic agents. But it's quite risky nevertheless, escpecially when (even small) overdoses of the involved drugs are used.
I am on 600mg Aurorix per day since about 2 weeks (300mg Moclobemide bid) . I will add 1.25mg Escitalopram on Friday and gradually increase the dose by 1.25mg every 5-7 days if I tolerate the mix good. My target Escitalopram dose is 10mg.
For security reasons I have Diazepam, Cyproheptadine and antihypertensive drugs at hand.
poster:Medline
thread:865206
URL: http://www.dr-bob.org/babble/20081123/msgs/865206.html