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Re: Adrenergic alpha-2 agonists? » Questionmark

Posted by yxibow on November 3, 2008, at 2:15:40

In reply to Adrenergic alpha-2 agonists?, posted by Questionmark on November 2, 2008, at 21:49:21

> Would these be helpful for benzo withdrawal at all? Like tizanidine or clonidine? I mean, not as a full substitute of course, but, partial.
> Anyhow good luck to all of you with that. It must be difficult.

Clonidine and Tenex are used for rage in ADHD children; as for anxiety, they are weak agents, at least in my experience -- I also tried Tenex for tics but that didn't work out -- anyhow that's a different issue.

There's also the issue of getting angioedema from agents like that and becoming sensitized. It is conceivable. However it is, they should not be stopped suddenly. They're heart drugs.

Propranolol would be a better choice, a dose judiciously chosen -- and definitely not at the same time as clonidine/guanfacine.

If you run a low pulse or low blood pressure it probably isn't a good idea to use a beta blocker because your heart is after all a muscle just like the peripherals that propranolol stabilize.

Non-cardioselective beta blockers should be used only really, basically propranolol -- they work on peripherals more, they're older and don't just touch the heart mostly like the more newer agents such as metoprolol.

 

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