Posted by uncouth on October 19, 2008, at 9:33:04
Hi, last question for me today. I'm on 40 Parnate plus 5mg Abilify and have felt better and more motivated than I have in a long time. However, I'm still feeling some residual anhedonia, and some restless legs at night, which along with the general feeling of insomnia that comes from parnate, has made sleep very difficult.
I've tried mirapex at night in the past for restless legs, and it has helped, at a relatively small dose. It also tends to make me sleepy when I've tried it during the day, so I figured it might be a worthy thing to try at night at a low dose (say 0.25- 0.50).
MY QUESTION: I'm hitting the dopamine receptors pretty hard with three things (possibly four, if I add a low dose of selegiline, see my other post). Doesn't seem to be a danger of combining parnate with abilify, but what about adding mirapex to the mix. At a low dose, will it counteract or magnify the effects of abilify on D2/D3 neurons?
I know it's all very complex, and different dosages hit presynaptic vs. postsynaptic receptors, but I'd hate to be causing dopamine chaos with an abilify plus mirapex combo.
Anyone have any experience with this?
poster:uncouth
thread:858222
URL: http://www.dr-bob.org/babble/20081016/msgs/858222.html