Posted by bulldog2 on September 28, 2008, at 8:41:14
In reply to Re: Sam-e Ad Combination For Incomplete Responders, posted by Tony P on September 27, 2008, at 21:23:33
> I've been experimenting a little with SAMe & various other Rx & OTC A/D's, because I had to cut back my Cymbalta for a while. I'm taking a very mixed cocktail, including Remeron, which I won't take the space to list completely right now, but I found:
>
> SAMe (moderate dosage, .4 - .8 gm/day) and low dose Selegeline (10 mg oral) were OK for me (CAUTION: Selegeline is an MAOI and you may react differently and dangerously, especially if you are on other A/Ds -- experiment _very_ carefully if at all & use a reliable home BP monitor).
>
> SAMe & St. John's Wort actually seemed to help each other -- the St.J.W. had a calming effect as against SAMe's edginess. Didn't try this for long, but it may be worth following up. BTW, there is some controversy as to whether St.J.W. _is_ an MAOI -- I'm not up-to-date, but the last paper I read said it _wasn't_ after all. I'm open to correction.
>
> SAMe + Reboxetine -- a little too stimulating, especially with Modafinil &/or Adrafinil, which I take prn when I'm getting into hypersomnia.
>
> I just wish SAMe wasn't so darned expensive. How much do people take who are on it long-term? One brand I bought said on the label (for depression) to start at .4-1.6 g. per day but cut back to .2-.4 g/day for maintenance. BTW, this is the tosylate form, which seems to be the only one readily available; there's an old thread here that says another formulation (sulfonate???) is much more bioavailable -- don't know why it's not sold (here in Canada anyway).
>
> Well, overall I'm a bit hypomanic on all these experimental combinations, but it's a lot more fun than the opposite!
>
> Tony PVitacost has some pharm grade sam-e at a reasonable price.
poster:bulldog2
thread:852512
URL: http://www.dr-bob.org/babble/20080926/msgs/854581.html